Fentanyl 100mcg patch (also known as fentanil) is a potent. Synthetic opioid pain medication with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Fentanyl is estimate to be between 50 and 100 times as potent as morphine.
Fentanyl 100mcg patch was first made by Paul Janssen. In 1960,following the medical inception of pethidine (also known as meperidine, market as Demerol) several years earlier. Janssen develop fentanyl by assaying analogues of the structurally relate drug pethidine for opioid activity.
The widespread use of fentanyl triggere the production of fentanyl citrate (the salt form by combining fentanyl and citric acid in a 1:1 stoichiometry), which enter medical use as a general anaesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogues were develop and introduce into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.
Fentanyl 100mcg
It is patch In the mid-1990s, fentanyl was introduce for palliative use with the fentanyl patch, follow in the next decade by the introduction of the fentanyl lollipop, dissolving tablets, and sublingual spray which are resorbe through the skin inside the mouth.As of 2012 fentanyl was the most widely use synthetic opioid in medicine.In 2013, 1700 kilograms were used globally.
Fentanyl is also use as a recreational drug, and this use has led to thousands of overdose deaths each year in recent years. Deaths have also result from improper medical use. Fentanyl has a relatively wide therapeutic index (270) which makes it a very safe surgical anesthetic when monitor carefully; however, its extreme potency requires careful measurements of highly diluted fentanyl in solution; attempting to accurately measure a dose of pure fentanyl powder is impractical without advanced scientific equipment. As an effective dose and a lethal dose of fentanyl powder placed next to each other would be difficult or impossible to differentiate with the naked eye
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